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The most commonly reported adverse effects in GLP-1 clinical trials include gastrointestinal symptoms such as nausea (occurring in 15-44% of patients depending on the specific agent and dose), vomiting, diarrhea, constipation, and abdominal pain

Detailed medical history was taken with special emphasis on age of onset and duration of the disease, frequency of epileptic attacks and number of hospital admissions due to severe attacks, as well as history of antiepileptic drugs (AEDs) (drug name, number of drugs, dosage, and duration of therapy)

Mid-life, higher levels of UA were associated with faster cognitive decline even after further adjustment (25-year global z-score difference, 0.149

Studied for anti-inflammatory effects in gastrointestinal research models, with NF-kB pathway modulation as the principal proposed mechanism